What is Gilbert Syndrome?
Gilbert Syndrome is the most common inherited disorder of bilirubin metabolism, characterized by periodic increases in the level of unconjugated bilirubin in the blood. The underlying cause is reduced activity of the enzyme UGT1A1, which is responsible for processing bilirubin in the liver.
This condition is considered benign: it does not cause liver damage, cirrhosis, or a shortened lifespan. It is often discovered incidentally during routine blood tests or may appear in adolescence with mild jaundice.
Mild jaundice (yellowing of the skin and eyes) that appears periodically
Triggering factors: stress, physical overexertion, fasting, infections, lack of sleep
Sometimes: fatigue, headaches, irritability, although most people feel well
The course of the condition is benign; symptoms may disappear on their own
Yes. It is inherited in an autosomal recessive manner, although sometimes it may appear even in carriers of a single defective gene copy.
No specific treatment is required.
Usually, it is enough to avoid triggering factors (fasting, excessive alcohol intake, stress).
In cases of significant jaundice, medications that stimulate enzyme activity (such as phenobarbital) may be used, but this is rarely necessary.
This condition is completely benign and does not shorten life expectancy. The only risks are cosmetic (visible jaundice) and the need to correctly distinguish it from other serious liver diseases.
Blood test (elevated unconjugated bilirubin with normal ALT, AST, ALP)
Absence of signs of liver damage or hemolysis
Provocative tests (bilirubin increase after fasting or exertion)
Genetic testing may confirm a mutation in the UGT1A1 gene
Gilbert Syndrome does not damage organs. It is simply a metabolic trait affecting bilirubin processing.
No cure is needed, as the syndrome is not dangerous and does not cause complications.
Explain to your child that this is a benign condition and does not harm their health.
Avoid triggering factors: prolonged fasting, excessive stress, large amounts of alcohol (in adulthood).
Regularly monitor liver function and bilirubin levels.
Do not restrict your child in physical activity or learning—they can live a completely normal life.
Every hryvnia you donate is a step towards health, a chance for treatment, and hope for a family.
SAVELIFEKIDS-UA helps children with severe liver diseases receive medical care, including transplants.
Together, we can do more.
Thank you for your support. 
© 2026 NGO “SAVELIFEKIDS-UA” Use of materials is permitted with a mandatory active link to the source.
